Author

D. Harris

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Evolutionary Biology· 2 Microbiology· 2 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Organism:bacteria (other)· 2 Research Focus:ecology & biodiversity· 2 Organism:non-human primate· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Kacar· 2 shared C. Ho· 2 shared F. J. Salguero· 2 shared H. E. Humphries· 2 shared K. A. Ryan· 2 shared L. Seefeldt· 2 shared S. Sharpe· 2 shared Y. Hall· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersEvolutionary Biology

B. Kacar

Mutual co-authors in cluster

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9 papers

Recent·Most cited

Surface Hydrophilicity Promotes Bacterial Twitching Motility

M. T. O'Hara, T. Shimozono, K. J. Dye, D. Harris, Z. Yang

This paper shows that bile salts and detergents enhance bacterial twitching motility by altering surface hydrophilicity, not by causing physiological stress.

mSphere · Sep 25, 2024Peer-reviewedMicrobiology

The Origins of ATP Dependence in Biological Nitrogen Fixation

D. Harris, H. Rucker, A. Garcia, Z.-Y. Yang, S. Chang, H. Feinsilber, B. Kacar, L. Seefeldt

This study experimentally reconstructs an ancestral nitrogenase enzyme and shows it strictly requires ATP hydrolysis for N2 reduction, decoupling cofactor selection from environmental availability.

bioRxiv · Feb 22, 2024 · PreprintEvolutionary Biology

Nitrogenase resurrection and the evolution of a singular enzymatic mechanism

A. K. Garcia, D. Harris, A. Rivier, B. Carruthers, A. P. Barros, L. Seefeldt, B. Kacar

This study resurrects ancient nitrogenase enzymes and shows their in vivo functionality and reversible dinitrogen reduction mechanism, suggesting evolutionary constraints in catalyzing this reaction.

eLife · Feb 17, 2023Peer-reviewedEvolutionary Biology

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

B. Becker, F. Wottawa, M. Bakr, E. Koncina, L. Mayr, J. Kugler, G. Yang, S. J. Windross, L. Neises, N. Mishra, D. Harris, F. Tran, L. Welz, J. Schwaerzler, Z. Banki, , K. Aden

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

bioRxiv · May 17, 2022 · PreprintCell Biology

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S. Rauch, K. E. Gooch, Y. Hall, F. J. Salguero, M. J. Dennis, F. V. Gleeson, D. Harris, C. Ho, H. E. Humphries, S. Longet, D. Ngabo, J. Paterson, E. L. Rayner, K. A. Ryan, S. Sharpe, , M. W. Carroll

This study shows that the mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 infection and reduces disease severity.

bioRxiv · Dec 23, 2020 · PreprintImmunology

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

K. R. Bewley, K. E. R. Gooch, K. M. Thomas, S. R. Longet, N. Wiblin, L. Hunter, K. Chan, P. Brown, R. A. Russell, C. Ho, G. Slack, H. E. Humphries, L. Alden, L. Allen, M. Aram, , M. Carroll

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

bioRxiv · Dec 21, 2020Pathology

High fat diet disrupts diurnal interactions between REG3g and small intestinal gut microbes resulting in metabolic dysfunction

K. Frazier, A. Kambal, E. A. Zale, J. F. Pierre, N. Hubert, S. Miyoshi, J. Miyoshi, D. Ringus, D. Harris, K. Yang, C. Cham, M. W. Musch, E. B. Chang, V. Leone

bioRxiv · Jun 17, 2020 · PreprintMicrobiology

Citizen scientists highlight conservation value of a small subtropical reef, Flinders Reef, southeast Queensland, Australia.

M. G. Grol, J. Vercelloni, T. M. Kenyon, E. Bayraktarov, C. P. van den Berg, D. Harris, J. A. Loder, M. Mihaljevic, P. I. Rowland, C. M. Roelfsema

Citizen scientists assessed Flinders Reef's ecological status, finding it healthy with low impacts and high coral diversity, suggesting expansion of its protection zone could enhance conservation.

bioRxiv · Apr 8, 2019 · PreprintEcology

Long-term community change through multiple rapid transitions in a desert rodent community

E. Christensen, D. Harris, M. Ernest

The paper analyzes long-term desert rodent community changes over 38 years, identifying three rapid reorganization events linked to low rodent abundance periods.

bioRxiv · Apr 25, 2018Ecology