Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC
K. H. Tang, S. Li, A. Khodadadi-Jamayran, J. Jen, H. Han, K. Guidry, T. Chen, Y. Hao, C. Fedele, J. Zebala, D. Maeda, J. Christensen, P. Olson, A. Athanas, K.-K. Wong, B. G. Neel
This study shows that combining SHP2 and CXCR1/2 inhibitors enhances anti-tumor T cell responses in NSCLC by reducing immunosuppressive gMDSCs and promoting effector T cells.
bioRxiv · Mar 21, 2021Cancer Biology