Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer
X. Tong, A. S. Patel, E. Kim, H. Li, Y. Chen, S. Li, S. Liu, J. Dilly, K. S. Kapner, Y. Xue, L. Hover, S. Mukhopadhyay, F. Sherman, K. Mynzdar, Y. Gao, , H. Ji
The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.
bioRxiv · Sep 7, 2023 · PreprintCancer Biology