Author

C. Fedele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. G. Neel· 2 shared K. H. Tang· 2 shared K.-K. Wong· 2 shared S. Li· 2 shared T. Chen· 2 shared A. Athanas· 1 shared A. Khodadadi-Jamayran· 1 shared A. Koide· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

B. G. Neel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prospective isolation according to melanin pigment content of melanoma cells with heterogeneous potentials for disease propagation

C. Fedele, G. Kuser Abali, R. Rossi, P. Zhao, J. Li, P. Szeto, Y. Zhang, N. C. Wong, M. Andrews, M. Shackleton

This study isolates melanoma cells based on melanin content, finding that low-pigment cells are more abundant and have higher tumorigenic potential than high-pigment cells.

bioRxiv · Oct 31, 2022Cancer Biology

Light-induced nanoscale deformation in azobenzene thin film triggers rapid intracellular Ca2+ increase via mechanosensitive cation channels

H. M. Peussa, C. Fedele, H. Tran, J. Fadjukov, E. Mäntylä, A. Priimägi, S. Nymark, T. O. Ihalainen

The paper uses light-induced nanoscale deformation of azobenzene thin films to study mechanosensitive Ca2+ signaling in cells, identifying Piezo1 as the key channel involved.

bioRxiv · Sep 27, 2022Bioengineering

Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC

K. H. Tang, S. Li, A. Khodadadi-Jamayran, J. Jen, H. Han, K. Guidry, T. Chen, Y. Hao, C. Fedele, J. Zebala, D. Maeda, J. Christensen, P. Olson, A. Athanas, K.-K. Wong, B. G. Neel

This study shows that combining SHP2 and CXCR1/2 inhibitors enhances anti-tumor T cell responses in NSCLC by reducing immunosuppressive gMDSCs and promoting effector T cells.

bioRxiv · Mar 21, 2021Cancer Biology

SHP2 Inhibition Abrogates Adaptive Resistance to KRASG12C-Inhibition and Remodels the Tumor Microenvironment of KRAS-Mutant Tumors

C. Fedele, S. Li, K. W. Teng, C. Foster, D. Peng, H. Ran, P. Mita, M. Geer, T. Hattori, A. Koide, Y. Wang, K. H. Tang, J. Leinwand, W. Wang, B. Diskin, , B. G. Neel

This study shows that combining SHP2 inhibitors with KRASG12C inhibitors enhances efficacy in PDAC and NSCLC by overcoming resistance and remodeling the tumor microenvironment.

bioRxiv · May 30, 2020Cancer Biology