ImmunologybioRxiv
Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19
S. Kamle, B. Ma, C. H. He…·J. A. Elias
This study identifies CHI3L1 as a key mediator of aging-related severity in COVID-19 by stimulating ACE2 and SPP expression, and shows it is a therapeutic target.
DOI 10.1172/jci.insight.148749