ImmunologybioRxivPreprint
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological dysregulation of NKG2Dhi CD8 killer T cells
E. Masle-Farquhar, K. J. L. Jackson, T. J. Peters…·C. C. Goodnow
This study shows that STAT3 gain-of-function mutations in leukemia drive autoimmune pathology by causing NKG2Dhi CD8 T cell oligoclonal expansion and cytotoxic activity.
DOI 10.1101/2022.02.11.480027