Author

K. Lanko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:virus· 1

Frequent Co-Authors

J. Neyts· 3 shared C. Mirabelli· 2 shared L. Delang· 2 shared P. Leyssen· 2 shared A. Bolleboom· 1 shared A. de Wilde· 1 shared A. von Brunn· 1 shared B. B. Oude Munnink· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

J. Neyts

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models

L. Bauer, S. Giussani, N. Palazzi, E. Bot, E. Colombo, F. Zare, F. Pinci, L. Leijten, K. Lanko, F. F. W. Benavides, H. Smeenk, C. W. E. Embregts, J. K. H. Spoor, C. Dirven, Z. Gao, , O. Harschnitz

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

bioRxiv · Aug 25, 2023 · PreprintMicrobiology

Comparative analysis of the molecular mechanism of resistance to vapendavir across a panel of picornavirus species

K. Lanko, L. Sun, M. Froeyen, P. Leyssen, L. Delang, C. Mirabelli, J. Neyts

The paper identifies mutations in picornaviruses that confer resistance to vapendavir, including both pocket and non-pocket mutations, and shows some mutations require drug presence for viral replication.

bioRxiv · Jul 16, 2020Microbiology

Assessing the in vitro resistance development in Enterovirus 71 in the context of combination antiviral treatment

K. Lanko, C. Shi, S. Patil, L. Delang, J. Matthijnssens, C. Mirabelli, J. Neyts

This study evaluates how combining antivirals with different mechanisms delays resistance development in EV-A71 to pirodavir.

bioRxiv · Feb 10, 2020 · PreprintMicrobiology

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

L. Zhang, D. Lin, Y. Kusov, Y. Nian, Q. Ma, J. Wang, A. von Brunn, P. Leyssen, K. Lanko, J. Neyts, A. de Wilde, E. J. Snijder, H. Liu, R. Hilgenfeld

This study identifies alpha-ketoamides as broad-spectrum inhibitors effective against coronavirus and enterovirus proteases, with compounds showing low-micromolar activity in cell cultures.

bioRxiv · Feb 10, 2020 · PreprintBiochemistry