Author

Y. Nian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Elkhal· 2 shared J. Iske· 2 shared A. de Wilde· 1 shared A. Ghouzlani· 1 shared A. S. Banks· 1 shared A. Tavakkoli· 1 shared A. Vasudevan· 1 shared A. von Brunn· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

A. Elkhal

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Restored TDCA and Valine Levels Imitate the Effects of Bariatric Surgery

S. G. Tullius, M. Quante, J. Iske, T. Heinbokel, B. N. Desai, H. R. C. Biefer, Y. Nian, F. Krenzien, H. Uehara, R. Maenosono, H. Azuma, J. Pratschke, C. Falk, T. Lo, E. Sheu, , A. Elkhal

The paper shows that restoring TDCA and valine levels in obese mice mimics the weight loss effects of bariatric surgery.

bioRxiv · Jan 11, 2021Cell Biology

NAD+ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages

J. Iske, R. El Fatimy, Y. Nian, A. Ghouzlani, S. Eskandari, H. R. Cetina Biefer, A. Vasudevan, A. Elkhal

This study shows NAD+ prevents septic shock by blocking non-canonical inflammasome activation and promoting IL-10 cytokine production in macrophages.

bioRxiv · Mar 29, 2020Immunology

Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication

L. Zhang, D. Lin, Y. Kusov, Y. Nian, Q. Ma, J. Wang, A. von Brunn, P. Leyssen, K. Lanko, J. Neyts, A. de Wilde, E. J. Snijder, H. Liu, R. Hilgenfeld

This study identifies alpha-ketoamides as broad-spectrum inhibitors effective against coronavirus and enterovirus proteases, with compounds showing low-micromolar activity in cell cultures.

bioRxiv · Feb 10, 2020 · PreprintBiochemistry

Structure and mechanism of human diacylglycerol acyltransferase 1

L. Wang, H. Qian, Y. Nian, Y. Han, Z. Ren, H. Zhang, L. Hu, B. V. V. Prasad, N. Yan, M. Zhou

This study determines the structure of hDGAT1 with a substrate, revealing its homodimeric organization and substrate-binding sites.

bioRxiv · Jan 6, 2020Biochemistry