Author

K. Midde

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. Lin· 1 shared F. Murray· 1 shared I. Kufareva· 1 shared I. Lopez-Sanchez· 1 shared M. Garcia-Marcos· 1 shared M. Ghassemian· 1 shared N. Aznar· 1 shared N. Kalogriopoulos· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

C. Lin

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1 paper

Recent·Most cited

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

N. Kalogriopoulos, I. Lopez-Sanchez, C. Lin, T. Ngo, K. Midde, S. Roy, N. Aznar, F. Murray, M. Garcia-Marcos, I. Kufareva, M. Ghassemian, P. Ghosh

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

bioRxiv · Aug 9, 2020Biochemistry