Author

I. Lopez-Sanchez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

P. Ghosh· 4 shared D. Sahoo· 3 shared C. Rohena· 2 shared I. Kufareva· 2 shared M. Ghassemian· 2 shared N. Aznar· 2 shared N. Kalogriopoulos· 2 shared S. Roy· 2 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCell Biology

P. Ghosh

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Author profile →

4 papers

Recent·Most cited

GIV/Girdin, a Non-receptor Modulator for Gαi/s, Regulates Spatiotemporal Signaling during Sperm Capacitation and is Required for Male Fertility

S. Reynoso, V. Castillo, G. D. Katkar, I. Lopez-Sanchez, S. Taheri, C. R. Espinoza, C. Rohena, D. Sahoo, P. Gagneux, P. Ghosh

This study shows GIV/Girdin regulates spatiotemporal signaling during sperm capacitation and is essential for male fertility by modulating distinct signaling programs in sperm tail and head.

bioRxiv · May 6, 2021Cell Biology

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

N. Kalogriopoulos, I. Lopez-Sanchez, C. Lin, T. Ngo, K. Midde, S. Roy, N. Aznar, F. Murray, M. Garcia-Marcos, I. Kufareva, M. Ghassemian, P. Ghosh

This study identifies how receptor tyrosine kinases activate heterotrimeric G proteins through phosphorylation of Gi's interdomain cleft tyrosines, revealing a tyrosine-based signaling mechanism with implications in cancer.

bioRxiv · Aug 9, 2020Biochemistry

GIV-Kindlin interaction is required for Kindlin-Mediated Integrin Recognition and Activation

C. Rohena, N. Kalogriopoulos, N. Rajapakse, S. Roy, I. Lopez-Sanchez, J. Ablack, D. Sahoo, P. Ghosh

This paper shows that GIV binds Kindlin-2 to enhance integrin activation, promoting cell adhesion and invasion, and links this interaction to metastasis in tumor transcriptomics.

bioRxiv · Dec 10, 2019Cell Biology

Convergence of Wnt, Growth Factor and Trimeric G protein signals on Daple

N. Aznar, Y. Dunkel, N. Sun, K. Satterfield, F. He, I. Lopez-Sanchez, M. Ghassemian, D. Sahoo, I. Kufareva, P. Ghosh

This study identifies Daple as a convergence point for Wnt, growth factor, and G-protein signaling in cancer, showing its role in tumor progression and poor prognosis in colorectal cancer.

bioRxiv · Jun 12, 2017Cancer Biology