Pharmacology & ToxicologybioRxivPreprint
Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist
Y. Maruyama, Y. Ohsawa, T. Suzuki…·T. Akiyama
This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.
DOI 10.1101/2023.05.08.539826