T. Ishikawa

Interaction between ciliary component proteins from Chlamydomonas revealed by CRISPR/CAS9, cryo-electron tomography and mass spectrometry

The paper investigates protein interactions in cilia using CRISPR/CAS9, cryo-ET, and mass spectrometry, revealing a complex involving FAP263, FAP78, FAP184, and FAP151, and links it to dynein f phosphorylation.

Assessing Target of Rapamycin (TOR) activity in the diatom Phaeodactylum tricornutum using commercially available materials

This study develops a Phos-tag-based method to assess TOR kinase activity in diatoms and other algae using commercially available materials, showing dose-dependent and nitrogen-deficient responses.

The Architecture of Sponge Choanocyte Chambers Maximizes Mechanical Pumping Efficiency

The paper investigates the mechanical pumping efficiency of sponge choanocyte chambers by combining imaging and computational models, finding that their spherical shape and outlet angle optimize flow.

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

AtDREB2G is a novel regulator of riboflavin biosynthesis under low-temperature stress and abscisic acid treatment in Arabidopsis thaliana

The D-mannose/L-galactose pathway plays a predominant role in ascorbate biosynthesis in the liverwort Marchantia polymorpha but is not regulated by light and oxidative stress

Glucose stockpile in the intestinal apical brush border in C. elegans

The paper measures glucose diffusion in C. elegans intestinal brush border, finding it significantly slower than in bulk, suggesting a glucose stockpile in this viscous layer.

SPHINGOLIPIDS AND DELTA8-SPHINGOLIPID DESATURASE FROM THE PICOALGA O. TAURI AND INVOLVEMENT IN TEMPERATURE ACCLIMATION

This study identifies and characterizes sphingolipid Δ8-desaturase in O. tauri, showing its temperature-dependent regulation and role in temperature acclimation through effects on cell size and chlorophyll.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

Acute irradiation alters the heterogeneity among medullary thymic epithelial cells 2

This study shows acute irradiation reduces AIRE-expressing mTECs and a unique Ccl25+ TSA-high mTEC cluster, altering mTEC heterogeneity and potentially impairing T cell self-tolerance.

Swimming, Feeding and Inversion of Multicellular Choanoflagellate Sheets

This study develops fluid dynamical and mechanical models to explain the swimming, feeding, and inversion of multicellular choanoflagellate sheets of Choanoeca flexa.

TCR Repertoire Analysis of CD4-Positive T Cells from Blood and an Affected Organ in an Autoimmune Mouse Model

This study examines TCR repertoires in CD4+ T cells from blood and stomachs of AIRE KO mice to correlate TCR diversity with autoimmune symptom variation and organ-specific disease manifestations.

Cryo-electron tomography sheds light on the largest protein in the Trypanosoma brucei tripartite attachment complex

This study uses cryo-electron tomography to analyze the tripartite attachment complex in Trypanosoma brucei, revealing the structural dynamics of the complex during kDNA segregation.

A highly contiguous genome assembly of red perilla (Perilla frutescens) domesticated in Japan

This paper presents a high-quality genome assembly of red perilla, identifying potential targets for genome editing to enhance metabolite production.

Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

The paper shows that glutamine deficiency in cancer cells prevents p53 activation by rRNA synthesis inhibitors, promoting survival during nutrient stress.

Non-glycosylated Seipin to Cause a Motor Neuron Disease Induces ER stress and Apoptosis by Inactivating the ER Calcium Pump SERCA2b

Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.

HSD11β1 promotes EMT-mediated breast cancer metastasis

This study identifies HSD11β1 as a promoter of breast cancer metastasis via EMT induction and shows that targeting HSD11β1 could suppress metastasis.

Genes for tRNA recycling are upregulated in response to infection with Theiler's mouse encephalitis virus

The paper investigates how viral infection affects tRNA recycling by analyzing mRNA levels of tRNase ZS and TRNT1 in HeLa cells, finding upregulation in response to Theiler's mouse encephalitis virus but not influenza A virus.

Conversion of cancer-associated fibroblasts from pro- to antitumor improves the sensitivity of pancreatic cancer to chemotherapeutics

This study converts pro-tumor CAFs to anti-tumor CAFs using Meflin induction, enhancing PDAC chemosensitivity through improved drug delivery and reduced tissue stiffness.

Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocyte accumulating hepatitis B surface antigen

Bacteroides uniformis enhances endurance exercise performance through gluconeogenesis

This study shows that Bacteroides uniformis in the gut enhances endurance exercise performance by increasing gluconeogenesis through acetate and propionate production.

Motility and Phototaxis of Gonium, the Simplest Differentiated Colonial Alga

This study investigates how Gonium achieves phototaxis through a combination of experimental, theoretical, and computational approaches, revealing that peripheral cells alone drive colony reorientation.

Cortisol levels adter cold exposure are independent of adrenocorticotropic hormone stimulation

This study shows that cortisol levels after cold exposure are not correlated with ACTH levels in human autopsies or in cell culture experiments.

SETD3 protein is the actin-specific histidine N-methyltransferase

This study identifies SETD3 as the actin-specific histidine N-methyltransferase in vertebrates, showing it methylates β-actin at H73 and affects actin dynamics and glycolytic activity.