T. Akiyama

This study generates functional adult hearts in Mesp1/2-deficient mice using blastocyst complementation with pluripotent stem cells, showing successful derivation of all cardiovascular lineages from exogenous cells.

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

This study shows acute irradiation reduces AIRE-expressing mTECs and a unique Ccl25+ TSA-high mTEC cluster, altering mTEC heterogeneity and potentially impairing T cell self-tolerance.

This study examines TCR repertoires in CD4+ T cells from blood and stomachs of AIRE KO mice to correlate TCR diversity with autoimmune symptom variation and organ-specific disease manifestations.

This study generates functional and long-lived melanocytes from human pluripotent stem cells using transient JMJD3 expression, showing melanogenesis and engraftability in mice.

This study identifies a TMPRSS2-independent metalloproteinase-dependent entry pathway for SARS-CoV-2 that requires the furin cleavage site and S2 domain of the spike protein, highlighting new therapeutic targets.

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

The paper quantitatively analyzes thymic crosstalk dynamics during recovery from irradiation, identifying regulatory interactions and predicting a new regulation of CD4+CD8+ thymocytes.