T. Miyao

Establishing a method for the cryopreservation of viable peripheral blood mononuclear cells in the International Space Station

This study develops a cryopreservation method for blood cells under ISS constraints, demonstrating viability recovery and subset analysis using flow cytometry.

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonist

This study identifies KSI-6666 as a pseudoirreversible S1PR1 antagonist that suppresses inflammation through interaction with a methionine residue.

Acute irradiation alters the heterogeneity among medullary thymic epithelial cells 2

This study shows acute irradiation reduces AIRE-expressing mTECs and a unique Ccl25+ TSA-high mTEC cluster, altering mTEC heterogeneity and potentially impairing T cell self-tolerance.

TCR Repertoire Analysis of CD4-Positive T Cells from Blood and an Affected Organ in an Autoimmune Mouse Model

This study examines TCR repertoires in CD4+ T cells from blood and stomachs of AIRE KO mice to correlate TCR diversity with autoimmune symptom variation and organ-specific disease manifestations.

Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.

Quantitative analysis reveals reciprocal regulations underlying recovery dynamics of thymocytes and thymic environment

The paper quantitatively analyzes thymic crosstalk dynamics during recovery from irradiation, identifying regulatory interactions and predicting a new regulation of CD4+CD8+ thymocytes.