K. Niazi

This study uses mRNA display to identify and engineer neutralizing antibodies against SARS-CoV-2 variants, revealing binding modes and demonstrating their effectiveness against mutations in the spike protein.

This study shows that CRTC2 repression is essential for plasma cell metabolism and survival, affecting antibody production and immune response durability.

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

The paper develops an ACE2 Triple Decoy that maintains high affinity for SARS-CoV-2 variants and shows enhanced affinity for specific mutations.

This study uses molecular dynamics simulations to show that the E484K mutation increases spike RBD-ACE2 affinity and that the combination of E484K, K417N, and N501Y mutations causes greater conformational changes, potentially leading to antibody escape.

The paper uses molecular dynamics simulations to study SARS-CoV-2 spike RBD interactions with ACE2, revealing an optimized binding conformation and potential targets for therapeutics.

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

The paper identifies a 32-gene immune signature in Treg-enriched tumor samples that correlates with chemosensitivity, overall survival, and immunogenic tumor microenvironment features.