TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination
R. Toy, M. C. Keenum, P. Pradhan, K. Phang, P. Chen, C. Chukwu, A. Nguyen, J. Liu, S. Jain, G. Kozlowski, J. Hosten, M. Suthar, K. Roy
This paper shows that combining TLR7 and RIG-I adjuvants in nanoparticles enhances dendritic cell responses and improves cellular immunity in influenza vaccination.
bioRxiv · Jul 17, 2020Bioengineering