Author

M. C. Keenum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. Roy· 3 shared A. C. Jimenez· 2 shared A. M. Atalis· 2 shared B. Pandey· 2 shared J. Hosten· 2 shared P. Pradhan· 2 shared A. Beach· 1 shared A. Nguyen· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBioengineering

K. Roy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-Cell Epitope-Transcriptomics Reveal Lung Stromaland Immune Cell Response Kinetics to Nanoparticle delivered RIG-I and TLR4 Agonists

M. C. Keenum, P. Chatterjee, A. M. Atalis, B. Pandey, A. C. Jimenez, K. Roy

This study uses CITE-seq to analyze lung cell responses to nanoparticle-delivered RIG-I and TLR4 agonists, showing early changes in gene expression and cytokine synthesis.

bioRxiv · Nov 29, 2022Bioengineering

Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine

A. M. Atalis, M. C. Keenum, B. Pandey, A. Beach, P. Pradhan, C. E. Vantucci, R. Jain, J. Hosten, C. Smith, L. L. Kramer, A. C. Jimenez, M. A. Armenta-Ochoa, D. A. Frey, K. Roy

This study shows that nanoparticle-delivered TLR4 and RIG-I agonists enhance immune responses to a SARS-CoV-2 subunit vaccine in mice, with route-specific effects on T and B cell responses.

bioRxiv · Jan 31, 2022Immunology

TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination

R. Toy, M. C. Keenum, P. Pradhan, K. Phang, P. Chen, C. Chukwu, A. Nguyen, J. Liu, S. Jain, G. Kozlowski, J. Hosten, M. Suthar, K. Roy

This paper shows that combining TLR7 and RIG-I adjuvants in nanoparticles enhances dendritic cell responses and improves cellular immunity in influenza vaccination.

bioRxiv · Jul 17, 2020Bioengineering