A screening platform based on epitope editing for drug discovery
B. Zhu, J. Yang, R. Van, K. Ran, K. Yin, Y. Liang, N. Shen, W. Yin, S. H. Choi, Y. Lu, C. Wang, Y. Shao, R. E. Tanzi, C. Zhang, Y. Cheng, , C. Ran
This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.
bioRxiv · Nov 24, 2019 · PreprintBiochemistry