K. Yin

This study investigates post-acute immunological and behavioral effects in mice after Omicron infection, showing vaccination reduces pulmonary immune perturbations and behavioral deficits.

This study identifies non-coding regulatory regions driving metastatic prostate cancer using an integrative computational and experimental approach.

This study identifies muscarinic receptor signaling as a key driver of platin-induced enteric neuropathy and shows that its inhibition protects neurons from toxicity.

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

This study uses label-free proteomics to analyze mouse astrocytes infected with different stages of Toxoplasma gondii, identifying differentially expressed proteins that reveal host response mechanisms in acute and chronic infections.

This study determines the cryo-EM structures of AAV9 and AAVPHP.eB in complex with their receptor AA VR, revealing molecular details of receptor recognition and explaining enhanced CNS transduction.

This study shows that deleting TSC22D4 in hepatocytes reduces liver damage in NASH by improving mitochondrial function and lipid metabolism.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

This study induces human adipose-derived mesenchymal stem cells into hepatocyte-like cells using small-molecule cocktails and growth factors, producing cells with mature phenotype and function.

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

This paper introduces a dynamic aqueous multiphase reaction system for rapid, sensitive, and quantitative CRISPR-Cas12a-based molecular diagnosis of HPV16/18 DNA.

The paper introduces AIOD-CRISPR, a dual CRISPR-Cas12a assay for rapid, ultrasensitive, and visual detection of SARS-CoV-2 and HIV with high sensitivity comparable to RT-PCR.

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.