Author

R. Van

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

A. Cheng· 2 shared A. Cuevas-Navarro· 2 shared B. Zhu· 2 shared C. Ran· 2 shared F. McCormick· 2 shared J. Yang· 2 shared P. Castel· 2 shared Y. Shao· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Cheng

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimers Disease Models

J. Zhang, C. Wickizer, W. Ding, R. Van, L. Yang, B. Zhu, J. Yang, C. M. Zhang, S. Shen, Y. Shao, C. Ran

This paper develops chemiluminescence probes for in vivo 3D brain imaging in Alzheimer's disease models, showing high photon emission and binding to amyloid beta.

bioRxiv · Jul 2, 2023Bioengineering

Ras-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

A. Cuevas-Navarro, M. Wagner, R. Van, M. Swain, M. R. Allison, A. Cheng, S. Messing, D. K. Simanshu, M. J. Sale, F. McCormick, A. G. Stephen, P. Castel

This study identifies how pathogenic RIT1 mutations drive RAF-MAPK hyperactivation in Noonan syndrome, showing MEK inhibition can alleviate cardiac hypertrophy in a mouse model.

bioRxiv · Nov 2, 2022Biochemistry

The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

A. Cuevas-Navarro, R. Van, A. Cheng, A. Urisman, P. Castel, F. McCormick

This study shows that RIT1, a Ras GTPase, suppresses the spindle assembly checkpoint, leading to mitotic errors and chromosome segregation defects.

bioRxiv · Nov 17, 2020Biochemistry

A screening platform based on epitope editing for drug discovery

B. Zhu, J. Yang, R. Van, K. Ran, K. Yin, Y. Liang, N. Shen, W. Yin, S. H. Choi, Y. Lu, C. Wang, Y. Shao, R. E. Tanzi, C. Zhang, Y. Cheng, , C. Ran

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

bioRxiv · Nov 24, 2019 · PreprintBiochemistry