C. Ran

Genome-wide association study of copy number variations in Parkinson's disease

This study conducts a genome-wide association study of copy number variations in Parkinson's disease, identifying a significant PRKN deletion but limited replication in an independent dataset.

The intestinal microbiome and Cetobacterium somerae inhibit viral infection through TLR2-type I IFN signaling axis in zebrafish

The study shows that the intestinal microbiome, specifically Cetobacterium somerae, inhibits viral infection in zebrafish via a TLR2-type I IFN signaling pathway.

Deciphering the gut microbiome of grass carp through multi-omics approach

The paper uses a multi-omics approach to analyze the gut microbiome of grass carp, identifying two functional groups and proposing a biomarker for microbiota structure and function.

In Vivo Three-dimensional Brain Imaging with Chemiluminescence Probes in Alzheimers Disease Models

This paper develops chemiluminescence probes for in vivo 3D brain imaging in Alzheimer's disease models, showing high photon emission and binding to amyloid beta.

Phototherapy with physically and molecularly produced light for Alzheimer's disease

This study shows that combining a photolabile Aβ ligand with LED or molecular light can reduce Aβ accumulation in mice, suggesting a new phototherapy approach for Alzheimer's disease.

Protein and Lipid Mass Concentration Measurement in Tissues by Stimulated Raman Scattering Microscopy

The paper introduces NoRI, a SRS microscopy method to measure protein, lipid, and water concentrations in tissues, showing cell-specific variations and disease-related changes in Alzheimer's models.

Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

β-Amyloid peptides tailor switching behaviors of Donor-Acceptor Stenhouse Adducts

The paper shows that β-Amyloid peptides modulate the switching behavior of donor-acceptor Stenhouse adducts, reducing molecular switching rates and inhibiting aggregation.

Dietary propionate induces intestinal oxidative stress via inhibition of SIRT3-mediated SOD2 depropionylation

This study shows dietary propionate causes intestinal oxidative stress in zebrafish by inhibiting SIRT3-mediated SOD2 depropionylation, leading to gut microbiota changes.

A screening platform based on epitope editing for drug discovery

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

Synthesis-Free PET Imaging Of Brown Adipose Tissue And TSPO Via Combination Of Disulfiram And 64CuCl2

This paper demonstrates a synthesis-free PET imaging method for brown adipose tissue and TSPO using Disulfiram and 64CuCl2, showing TSPO as a biomarker for BAT mass.