K. Schindler

A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development

This study identifies a germline-specific DSN1 splice isoform essential for oocyte maturation and early embryonic development in mammals.

Spatio-temporal requirements of Aurora kinase A in mouse oocytes meiotic spindle building

This study identifies the spatio-temporal roles of AURKA in mouse oocyte meiotic spindle formation using genetic and imaging approaches.

Distinct Aurora B pools at the inner centromere and kinetochore have different contributions to meiotic and mitotic chromosome segregation

The paper investigates how different Aurora B/C kinase recruitment pathways contribute to meiotic and mitotic chromosome segregation in budding yeast and mouse oogenesis.

The E2 SUMO-conjugating enzyme UBE2I coordinates the oocyte and zygotic transcriptional programs

This study shows that oocyte-specific deletion of Ube2i leads to meiotic arrest, defective spindles, and premature zygotic transcriptional activation in mice.

A meiotic midbody structure in mouse oocytes acts as a barrier for nascent translation to ensure developmental competence

This study identifies a meiotic midbody structure in mouse oocytes that acts as a barrier to prevent nascent translation from escaping into polar bodies, ensuring embryonic developmental competence.

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

This study creates a mutator parasite of Plasmodium falciparum to enhance drug resistance discovery by increasing mutation rates and identifying resistance mechanisms.

Aurora kinase A is essential for meiosis in mouse oocytes

This study shows that Aurora kinase A is essential for meiosis I in mouse oocytes, with functions distinct from AURKB and AURKC, and identifies multiple critical roles in spindle formation and chromosome segregation.

Aurora B and C kinases regulate prophase exit and chromosome segregation during spermatogenesis

The paper shows Aurora B and C kinases are essential for synaptonemal complex disassembly and accurate chromosome segregation in spermatogenesis, with functional compensation between them.