Author

K. Seidel

Primary ORCID profile (0000-0002-2609-3992 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

K. SeideliD1 paper · Max Planck Institute for Human Cognitive and Brain Sciences

Biology Disciplines

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Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

I. Kramnik· 2 shared A. Gimelbrant· 1 shared B. Bhattacharya· 1 shared B. N. Kholodenko· 1 shared E. Brownhill· 1 shared H. A. Chen· 1 shared I. Gavrish· 1 shared L. Kobzik· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPathology

I. Kramnik

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2 papers

Recent·Most cited

Dissemination and progression of pulmonary Mycobacterium avium infection in mouse model are associated with type 2 macrophage activation

R. Rosenbloom, I. Gavrish, K. Seidel, I. Kramnik, N. A. Crossland

This study shows that B6.Sst1S mice develop more severe pulmonary M. avium infection with increased type 2 macrophage activation and reduced T cell density compared to wild-type mice.

bioRxiv · Jun 23, 2021 · PreprintPathology

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov, O. S. Rukhlenko, K. Seidel, B. Bhattacharya, S. Chatterjee, H. A. Chen, N. Crossland, W. Bishai, B. N. Kholodenko, A. Gimelbrant, L. Kobzik, I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

bioRxiv · Dec 14, 2020 · PreprintImmunology