Author

V. Zhernovkov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. N. Kholodenko· 2 shared I. Kramnik· 2 shared L. Kobzik· 2 shared O. S. Rukhlenko· 2 shared S. M. Yabaji· 2 shared A. A. Gimelbrant· 1 shared A. Gimelbrant· 1 shared A. Grover· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersImmunology

B. N. Kholodenko

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Author profile →

3 papers

Recent·Most cited

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis Susceptibility

S. M. Yabaji, V. Zhernovkov, P. B. Araveti, S. Lata, O. S. Rukhlenko, S. A. Abdullatif, A. Vanvalkenburg, Y. Alekseev, Q. Ma, G. Dayama, N. C. Lau, W. E. Johnson, W. R. Bishai, N. A. Crossland, J. D. Campbell, , I. Kramnik

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

bioRxiv · Mar 5, 2024Immunology

Small gene networks can delineate immune cell states and characterize immunotherapy response in melanoma

D. Egan, M. Kreileder, M. Nabhan, L. F. Iglesias-Martinez, S. Dovedi, V. Valge-Archer, A. Grover, R. Wilkinson, T. Slidel, C. Bendtsen, I. Barrett, D. Brennan, W. Kolch, V. Zhernovkov

This paper uses small transcription factor-directed co-expression networks to deconvolute immune cell states from bulk RNA-seq data and characterize immunotherapy response in melanoma.

bioRxiv · Jul 11, 2022Immunology

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov, O. S. Rukhlenko, K. Seidel, B. Bhattacharya, S. Chatterjee, H. A. Chen, N. Crossland, W. Bishai, B. N. Kholodenko, A. Gimelbrant, L. Kobzik, I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

bioRxiv · Dec 14, 2020 · PreprintImmunology