Cell context-specific Synthetic lethality Prediction and Mechanism Analysis
Y. XIn, M. Pu, K. Tian, K. Cheng, L. Wei, W. Zheng, G. Peng, J. Zhou, Y. Zhang
This paper introduces SLWise, a deep-learning model for predicting synthetic lethal interactions in specific cellular contexts, and SLAD-CE for analyzing their mechanisms, showing improved accuracy over existing methods.
bioRxiv · Sep 13, 2023 · PreprintCancer Biology