G. Peng

Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner

This study shows that irisin deletion affects murine osteocyte function differently in males and females, with protection in females under calcium deficiency and increased bone loss in males.

Cell context-specific Synthetic lethality Prediction and Mechanism Analysis

This paper introduces SLWise, a deep-learning model for predicting synthetic lethal interactions in specific cellular contexts, and SLAD-CE for analyzing their mechanisms, showing improved accuracy over existing methods.

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

This study generates functional posterior spinal motor neurons from hPSCs-derived neural progenitor cells, demonstrating efficient differentiation and functional maturity.

Stem embolism vulnerability curve depends on methods used: is there a fifth mechanism of cavitation?

This paper investigates how different methods for measuring stem embolism vulnerability affect results, finding that nano-particles may induce early cavitation and that the origin of these particles might be from living cells near vessels.

A quadratic analytical solution of root pressure generation provides insights about bamboo and other species

The paper derives an analytical solution for root pressure and applies it to a 7-meter bamboo shoot's hydraulic architecture.

Insight into vaccine development for Alpha-coronaviruses based on structural and immunological analyses of spike proteins

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.

A Unit Pipe Pneumatic model to simulate gas kinetics during measurements of embolism in excised angiosperm xylem

The paper develops a Unit Pipe Pneumatic model to simulate gas diffusion kinetics in xylem embolism measurements and finds it overestimates embolism resistance by 2-17%.

The Preclinical Inhibitor GS441524 in Combination with GC376 Efficaciously Inhibited the Proliferation of SARS-CoV-2 in the Mouse Respiratory Tract

This paper evaluates the antiviral efficacy of GS441524 and GC376 combination therapy against SARS-CoV-2 in a mouse model, showing synergistic effects and protection with low-dose combined treatment.

Conserved epigenetic regulatory logic infers genes governing cell identity

This study introduces a computational method to identify genetic regulators of cell identity using epigenetic data across diverse species and validates findings with CRISPR experiments.

Identifying molecular features that are associated with biological function of intrinsically disordered protein regions

The paper identifies molecular features in intrinsically disordered protein regions that predict functional roles and validates their importance in mitochondrial targeting.

DNA methylation is indispensable for leukemia inhibitory factor dependent embryonic stem cells reprogramming

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

Study on Spatial-temporal Variation of Atmospheric Pollution in China between 2014 and 2019

The paper analyzes spatial-temporal variations of seven atmospheric pollutants in 370 Chinese cities from 2014 to 2019, revealing regional concentration patterns and temporal trends, with mixed improvements noted by 2019.

Cell-of-Origin Analysis of Metastatic Gastric Cancer Uncovers the Origin of Inherent Intratumor Heterogeneity and a Fundamental Prognostic Signature

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

Temporal modulation of host aerobic glycolysis determines the outcome of M. marinum infection

This study shows that pre-infection modulation of host glycolysis with 2-DG enhances resistance to M. marinum infection by reducing phagocytosis and bacterial proliferation.

Identification, Genotyping, and Pathogenicity of Trichosporon spp. Isolated from Giant Pandas

This study identifies and genotypes Trichosporon species isolated from giant pandas, finding 11 species with varying pathogenicity and genotypes.

PARPi triggers STING-dependent immune response and enhances therapeutic efficacy of immune checkpoint blockade independent of BRCAness

This study shows PARP inhibitors trigger an immune response via the STING pathway, enhancing immune checkpoint blockade efficacy regardless of BRCA mutations.