M. Pu

ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans

This study identifies ELO-6 expression as a predictor of longevity in isogenic C. elegans populations and shows its regulation by PQM-1.

Cell context-specific Synthetic lethality Prediction and Mechanism Analysis

This paper introduces SLWise, a deep-learning model for predicting synthetic lethal interactions in specific cellular contexts, and SLAD-CE for analyzing their mechanisms, showing improved accuracy over existing methods.

Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model.

Deep Learning model accurately classifies metastatic tumors from primary tumors based on mutational signatures

The paper develops a deep learning model that classifies metastatic tumors from primary tumors using mutational signatures from genomic data.

Pathogen effector-associated nuclear-localization of RPW8.2 amplifies its expression to boost immunity in Arabidopsis

The paper identifies a fungal effector that enhances RPW8.2 nuclear localization and transcription, boosting immunity in Arabidopsis against powdery mildew.

Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

Proteasome maturation factor UMP1 confers broad-spectrum disease resistance by modulating H2O2 accumulation in rice

A natural allele of rice UMP1 promotes resistance to multiple pathogens by boosting H2O2 accumulation.

Insights into the susceptibility of rice to a floral disease

The fungal pathogen Ustilaginoidea virens disarms chitin-triggered immunity in rice flower via a secreted chitinase, revealing a mechanism of disease susceptibility.

bHLH11 inhibits bHLH IVc proteins by recruiting the TOPLESS/TOPLESS-RELATED corepressors in Arabidopsis

The paper identifies bHLH11 as a negative regulator of Fe homeostasis in Arabidopsis, showing it inhibits bHLH IVc transcription factors by recruiting TOPLESS/TOPLESS-RELATED corepressors.

FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT) interacts with OsIRO2 to regulate iron homeostasis

OsFIT interacts with OsIRO2 to enhance its nuclear accumulation and activate Fe-uptake gene expression in rice.