A Novel ARNT-Dependent HIF-2α Signaling as a Protective Mechanism for Cardiac Microvascular Barrier Integrity and Heart Function Post-Myocardial Infarction
K. Ullah, L. Ai, Y. Li, L. Liu, Q. Zhang, K. Pan, Z. Humayun, L. Piao, A. Sitikov, Q. Su, Q. Zhao, W. W. Sharp, Y. Fang, D. Wu, J. K. Liao, R. Wu
This study identifies HIF2/ARNT as a protective axis in cardiac endothelial cells post-MI, preventing vascular leakage and inflammation through suppression of IL6.
bioRxiv · Mar 12, 2023 · PreprintCell Biology