BiochemistrybioRxiv
The biosynthetic gene cluster of the C-nucleoside antibiotic pyrazomycin with a rare pyrazole moiety
G. Zhao, S. Yao, K. W. Rothchild…·Y.-L. Du
This study identifies the gene cluster and key enzymes involved in pyrazomycin biosynthesis in Streptomyces candidus, revealing the role of PyrR as a transcriptional activator and PyrN as a nitrogen-nitrogen bond-forming enzyme.
DOI 10.1002/cbic.201900449