S. Yao

Single-cell dissection of prognostic architecture and immunotherapy response in Helicobacter pylori infection associated gastric cancer

This study analyzes single-cell transcriptomes of gastric cancer with and without H. pylori infection to identify immune and angiogenic signatures predictive of immunotherapy response.

Biomarker Identification by Proteomic Analysis of Vitreous Humor and Plasma in Diabetic Retinopathy

This study identifies protein biomarkers in vitreous humor and plasma that predict diabetic retinopathy progression, with significant changes observed in vitreous samples of PDR patients.

Convergent evolution of plant prickles is drivenby repeated gene co-option over deep time

The paper investigates convergent evolution of plant prickles, finding that mutations in a cytokinin gene repeatedly cause prickle loss across species.

Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis

This study identifies the cooperative role of c-MYC and KLF6-SV1 in promoting prostate cancer progression and metastasis through proteomic and genetic analyses in mouse models.

Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

This paper develops magnetic implants paired with a wearable device to wirelessly measure biophysical and biochemical signals in rats.

The microbial community of rust layer biofilm was driven by seawater microbial community

The paper analyzes microbial communities in rust layer biofilm and seawater, identifying dominant taxa and their interactions, and provides insights into microbial corrosion mechanisms in marine environments.

Alternating Polarity as a Novel Strategy for Cultivating Electro-Methanogenic Microbial Communities Capable of Robust Biogas Production

This paper develops an alternating polarity strategy to cultivate electro-methanogenic microbial communities, resulting in higher biogas production and structurally distinct communities.

Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells

This study shows that sorafenib can prolong lung cancer response to EGFR inhibitors by targeting resistant cells' selective advantage.

Targeting CD301+ macrophage inhibits endometrial fibrosis and improves pregnancy outcome

This study identifies CD301+ macrophages as drivers of endometrial fibrosis and infertility, showing their inhibition improves pregnancy outcomes in mice.

Alterations in intestinal Proteobacteria and antimicrobial resistance gene burden in individuals administered microbial ecosystem therapeutic (MET-2) for recurrent Clostridioides difficile infection

This study compares the effects of MET-2 and FMT on reducing Proteobacteria and antimicrobial resistance genes in patients with recurrent C. difficile infection.

Mechanical force induces DRP1-dependent asymmetrical mitochondrial fission for quality control

The paper shows mechanical force induces DRP1-dependent asymmetrical mitochondrial fission, leading to mtDNA-free fragments that recruit Parkin proteins.

Robust eIF4B levels undermine invasive growth and immune evasion mechanisms in murine triple negative breast cancer models.

This study shows that higher eIF4B levels in murine triple negative breast cancer models are linked to less aggressive tumor growth and better patient outcomes.

Net-shaped DNA nanostructure designed for rapid/sensitive detection and potential inhibition of SARS-CoV-2 virus

The paper designs a DNA nanostructure for rapid, sensitive, and inexpensive detection of SARS-CoV-2 and demonstrates its potential to inhibit viral infection.

Lipid-mediated nuclear moonlighting of cytosolic glyceraldehyde-3-phosphate dehydrogenase in plant heat response

The paper shows that phosphatidic acid, produced by phospholipase Dδ, mediates the nuclear translocation of cytosolic GAPC under heat stress in plants.

Histone neutralization in a rat model of acute lung injury induced by double-hit lipopolysaccharide

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

Deep-Learning Super-Resolution Microscopy Reveals Nanometer-Scale Intracellular Dynamics at the Millisecond Temporal Resolution

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

Structural Basis of Substrate Recognition by the Mitochondrial ADP/ATP Transporter

The paper identifies a new substrate recognition site in the mitochondrial ADP/ATP transporter AAC, revealing its role in ADP selectivity and transport mechanism.

Linking Population Dynamics to Microbial Kinetics for Hybrid Modeling of Engineered Bioprocesses

The paper develops a hybrid modeling strategy integrating microbial population dynamics and data-driven approaches to predict bioprocess outcomes with high accuracy.

The biosynthetic gene cluster of the C-nucleoside antibiotic pyrazomycin with a rare pyrazole moiety

This study identifies the gene cluster and key enzymes involved in pyrazomycin biosynthesis in Streptomyces candidus, revealing the role of PyrR as a transcriptional activator and PyrN as a nitrogen-nitrogen bond-forming enzyme.

Characterization of the workplace chemical exposome using untargeted LC-MS/MS: a case study

This study uses untargeted LC-MS/MS to analyze chemical exposures in three workplace types, identifying how building purpose, surface materials, and location affect chemical signatures and human exposure.

Traction force screening enabled by compliant PDMS elastomers

This paper introduces a high-throughput traction force screening method using compliant PDMS elastomers to measure cell contractility in multiple cell types.