T. Le

High-Resolution In Silico Painting with Generative Models

This paper introduces a simplified VQGAN training scheme for generating multi-channel organelle staining from bright field images, achieving top performance in a benchmark challenge.

Regulation of Oocyte Meiotic Maturation: Unraveling the Interplay between PKA Inhibition and Cdk1 Activation

This study investigates how PKA inhibition and Cdk1 activation interact to regulate oocyte meiotic maturation, revealing two waves of translation and feedback loops that drive the G2/M transition.

Endothelial TMEM16F lipid scramblase regulates angiogenesis

This study identifies TMEM16F as a regulator of angiogenesis through intracellular signaling, showing impaired retinal angiogenesis in TMEM16F-deficient mice and altered VE-cadherin and Src kinase activity in human endothelial cells.

Cross-species analysis of ARPP19 phosphorylation during oocyte meiotic maturation charts the emergence of a new cAMP-dependent role in vertebrates

This study compares ARPP19 phosphorylation in Xenopus and Clytia to resolve the cAMP paradox in oocyte maturation, showing differences in PKA and Gwl phosphorylation sites and their functional roles.

Sequence Controlled Secondary Structure Determines Site-selectivity of Lanthipeptides

This study shows that the secondary structure of lanthipeptide substrates determines site-selectivity and ring formation order, independent of the dehydration step.

Liquid droplet aging and fibril formation of the stress granule protein TIA1 low complexity domain

This study investigates how aging and mutations affect the fibril formation of the TIA1 low complexity domain, showing disease mutations do not favor specific fibril conformations.

Methylothon: a versatile course-based high school research experience in microbiology and bioinformatics-- with pink bacteria

Methylothon is a high school research module on microbiology and bioinformatics using pink bacteria, offering both in-person and remote versions with bioinformatics tools and community science participation.

Simultaneous Cardiac and Neurological Monitoring to Assess Chemical Exposures and Drug Toxicity in Xenopus Laevis

This paper develops a microelectrode array system for real-time ECG and EEG monitoring in Xenopus laevis under chemical exposure, demonstrating its ability to detect drug-induced physiological changes.

Quantitation of human enteric viruses as alternative indicators of fecal pollution to evaluate wastewater treatment processes

The paper quantifies human enteric viruses in wastewater samples to assess their potential as indicators of fecal pollution and evaluates their reduction across treatment stages.

A Novel Art of Electrocardiogram Assessment in Zebrafish for Cardiovascular Disease Studies and Drug Screening

This study develops a novel ECG monitoring system for zebrafish to assess cardiovascular function and drug effects, showing improved efficiency and reduced side effects.

Anaerobic derivates of mitochondria and peroxisomes in the free-living amoeba Pelomyxa schiedti revealed by single-cell genomics

This study identifies anaerobic mitochondrial and peroxisomal derivatives in Pelomyxa schiedti using single-cell genomics and electron microscopy.

An inconvenient association between granzyme A and Nicotinamide Nucleotide Transhydrogenase

The paper identifies an association between granzyme A and Nicotinamide Nucleotide Transhydrogenase in mice, showing that Nnt, not GzmA loss, affects disease outcomes and highlights inconsistencies in Nnt sequencing data.

CD47 as a potential biomarker for the early diagnosis of severe COVID-19

This study identifies CD47 as a potential biomarker for early diagnosis of severe COVID-19 by showing its increased levels in SARS-CoV-2 infection and association with risk factors and complications.

Talaromyces marneffei promotes M2 polarization of human macrophages by downregulating SOCS3 expression and activating TLR9 pathway

This study shows Talaromyces marneffei induces M2 macrophage polarization by downregulating SOCS3 and activating TLR9, enhancing fungal survival.

Data driven mathematical model of colon cancer progression

This study develops a data-driven mathematical model to analyze immune microenvironment interactions in colon cancer, revealing varying effects of macrophage activation on tumor progression across patient groups.

Simple rapid in vitro screening method for SARS-CoV-2 anti-virals that identifies potential cytomorbidity-associated false positives

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

The paper identifies BET inhibitors as potential cardio-protective drugs that block inflammation-induced cardiac dysfunction and SARS-CoV-2 infection in pre-clinical models.

Core binding factor leukemia hijacks T-cell prone PU.1 antisense promoter

The paper shows that CBF fusions in AML activate the PU.1 antisense promoter, reducing sense PU.1 transcription and blocking myeloid differentiation, similar to T-cell differentiation.

Manipulation-based skills for anthropomorphic human-arm system based on integrated ANFIS and vector calculus

The paper develops new inverse kinematics solutions for a 5-DOF robotic arm using vector calculus and ANFIS, showing improved accuracy and performance.

The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division

The paper identifies PP2A-B55δ as the phosphatase that dephosphorylates Arpp19 at S109, counteracting PKA to release oocytes from meiotic prophase.

TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development

This study identifies TMEM16F as a phospholipid scramblase essential for trophoblast fusion and placental development by externalizing phosphatidylserine.

Biophysical and physiological causes of coral reef microbialization

The paper investigates how oxygen loss from fleshy macroalgae leads to microbialization of coral reefs by increasing DOC:O2 ratios, promoting bacterial biomass accumulation.