Audrey Gérard

This study shows that CXCR3 on transferred T cells enhances the effectiveness of combining adoptive T-cell therapy with viral-vector vaccines in solid tumors.

This study shows that chemotherapy, specifically CarboTaxol, synergizes with cancer vaccines and anti-PD-1 to improve tumor control and survival by expanding stem-like TCF1+CD8+ T cells.

The paper shows TRIM21 becomes an autoantigen by forming pro-inflammatory immune complexes after lytic cell death, which are taken up by macrophages and drive inflammation.

The paper shows that transient immune architecture changes during infection protect low-affinity CD8 T-cell priming from Treg inhibition, ensuring broad T-cell responses.

This study shows that the breast tumor microenvironment transforms eosinophils into a less active state by reducing Ly6C expression, impairing their anti-tumor function, and that IFN stimulation can partially restore this phenotype.

This paper measures 3D affinities of the OT-I TCR to 19 pMHC complexes and finds they strongly correlate with 2D membrane affinities, revealing imperfect antigen discrimination.

The paper shows that IFN-gamma-insensitive tumours can still be controlled by immune responses, with IFN-gamma driving myeloid cell remodelling that enhances anti-tumour immunity.