Author

L. Ames

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

C. Bonifer· 2 shared H. Blair· 2 shared P. Keane· 2 shared P. S. Chin· 2 shared S. G. Kellaway· 2 shared S. Potluri· 2 shared A. Adamo· 1 shared A. Butts· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

C. Bonifer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An arylsulphonamide that targets cell wall biosynthesis in Mycobacterium tuberculosis

R. Allen, L. Ames, V. P. Baldin, A. Butts, K. J. Henry, D. Quach, J. Sugie, J. Pogliano, T. Parish

The paper investigates an arylsulphonamide's mechanism against Mycobacterium tuberculosis, finding it targets cell wall biosynthesis via MmpL3.

bioRxiv · Jul 22, 2024 · PreprintMicrobiology

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

D. J. L. Coleman, P. Keane, R. Luque-Martin, P. S. Chin, H. Blair, L. Ames, S. G. Kellaway, J. Griffin, E. Holmes, S. Potluri, S. A. Assi, J. H. Bushweller, O. T. Heidenreich, P. Cockerill, C. Bonifer

The paper identifies critical transcription factor regulons in FLT3-ITD+ AML by analyzing gene regulatory networks and shows their necessity for AML growth.

bioRxiv · Jul 18, 2023Cancer Biology

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

S. G. Kellaway, S. Potluri, P. Keane, H. Blair, P. S. Chin, A. Ptasinska, A. Worker, L. Ames, A. Adamo, D. J. Coleman, N. Khan, S. Assi, A. Krippner-Heidenreich, M. Raghavan, P. N. Cockerill, , C. Bonifer

This study identifies VEGF and IL-5 signalling pathways as aberrantly activated in t(8;21) leukemic stem cells, enabling their growth and relapse.

bioRxiv · Mar 10, 2023Cancer Biology

A host-pathogen interaction screen identifies ada2 as a mediator of Candida glabrata defences against reactive oxygen species

I. Kounatidis, L. Ames, R. Mistry, H.-l. Ho, K. Haynes, P. Ligoxygakis

This study identifies ADA2 as a key mediator of Candida glabrata's resistance to reactive oxygen species in host defense.

bioRxiv · Jan 17, 2018Microbiology