Author

S. A. Assi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Elder· 1 shared A. Komkov· 1 shared A. Ptasinska· 1 shared A. Smith· 1 shared C. A. Cargo· 1 shared C. Bonifer· 1 shared C. Eckert· 1 shared C. J. Harrison· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Elder

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2 papers

Recent·Most cited

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

D. J. L. Coleman, P. Keane, R. Luque-Martin, P. S. Chin, H. Blair, L. Ames, S. G. Kellaway, J. Griffin, E. Holmes, S. Potluri, S. A. Assi, J. H. Bushweller, O. T. Heidenreich, P. Cockerill, C. Bonifer

The paper identifies critical transcription factor regulons in FLT3-ITD+ AML by analyzing gene regulatory networks and shows their necessity for AML growth.

bioRxiv · Jul 18, 2023Cancer Biology

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

R. Tirtakusuma, K. Szoltysek, P. Milne, V. V. Grinev, A. Ptasinska, C. Meyer, S. Nakjang, J. Y. Hehir-Kwa, D. Williamson, P. Cauchy, S. A. Assi, M. R. Imperato, F. Vogiatzi, S. Lin, M. Wunderlich, , M. J Thirman

This study shows that lineage switching in MLL-AF4 leukaemia is driven by dysregulation of epigenetic regulators like NuRD, leading to reprogramming of gene regulatory networks from B lymphoid to myeloid.

bioRxiv · Jul 16, 2021Cancer Biology