Author

L. C. West

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. P. West· 2 shared C. W. Tong· 2 shared J. D. Bryant· 2 shared Y. Lei· 2 shared A. Mohan· 1 shared B. Wang· 1 shared C. E. Birdwell· 1 shared C. G. Martinez· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. P. West

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ImmunologybioRxivMay 30, 2022

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Y. Lei, J. J. Vanportfliet, Y.-F. Chen…·A. P. West

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

DOI 10.1016/j.cell.2023.05.039

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivSep 22, 2020

Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice

Y. Lei, C. G. Martinez, S. Torres-Odio…·A. P. West

This study shows that type I interferon activation worsens metabolic issues, inflammation, and aging in mice with mitochondrial DNA mutations.

DOI 10.1126/sciadv.abe7548

mousemechanistic / dynamical model

𝕏 PostBluesky

BiochemistrybioRxivJul 28, 2020

A Versatile Soluble Siglec Scaffold for Sensitive and Quantitative Detection of Glycan Ligands

E. Rodrigues, J. Jung, H. Park…·M. S. Macauley

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.

DOI 10.1038/s41467-020-18907-6

humanproteomics

𝕏 PostBluesky