BiochemistrybioRxiv
Casein kinase 1 dynamics underlie the PER2 circadian phosphoswitch
J. M. Philpott, R. Narasimamurthy, C. G. Ricci…·C. L. Partch
This study identifies a molecular switch in CK1 that regulates PER2 stability through substrate selectivity, revealing how kinase mutations affect circadian rhythms across species.
DOI 10.7554/elife.52343