Author

J. M. Philpott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

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Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell signaling & trafficking· 2 Organism:Drosophila· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:mouse· 1

Frequent Co-Authors

C. L. Partch· 3 shared A. M. Freeberg· 2 shared C. G. Ricci· 2 shared D. M. Virshup· 2 shared R. Narasimamurthy· 2 shared S. R. Hunt· 2 shared S. Tripathi· 2 shared C. L. Gustafson· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

C. L. Partch

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Author profile →

3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 4, 2022

CHRONO participates in multi-modal repression of circadian transcriptional complexes

P. Crosby, N. F. Goularte, D. Sharma…·C. L. Partch

This paper identifies CHRONO as a repressor of the circadian clock by modulating interactions between BMAL1 and PER2, revealing its role in fine-tuning circadian rhythmicity.

DOI 10.1101/2022.10.04.510902

mouseproteomics

𝕏 PostBluesky

BiochemistrybioRxivJun 24, 2022

PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period

J. M. Philpott, A. M. Freeberg, J. Park…·C. L. Partch

This study shows that PER phosphorylation inhibits CK1 activity, stabilizing PER and extending circadian period through feedback inhibition.

DOI 10.1016/j.molcel.2023.04.019

humanDrosophila

𝕏 PostBluesky

BiochemistrybioRxivAug 14, 2019

Casein kinase 1 dynamics underlie the PER2 circadian phosphoswitch

J. M. Philpott, R. Narasimamurthy, C. G. Ricci…·C. L. Partch

This study identifies a molecular switch in CK1 that regulates PER2 stability through substrate selectivity, revealing how kinase mutations affect circadian rhythms across species.

DOI 10.7554/elife.52343

humanDrosophila

𝕏 PostBluesky