C. L. Partch

Potassium rhythms couple the circadian clock to the cell cycle

The paper shows that circadian rhythms in intracellular potassium levels regulate the cell cycle in algae and mammalian cells.

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1

This study shows that isoform-specific phosphorylation in the C-terminal tail of CK1δ regulates its autoinhibition and affects circadian rhythms.

Conformationally responsive dyes enable protein-adaptive Differential Scanning Fluorometry

This paper introduces paDSF, a protein-adaptive Differential Scanning Fluorometry method that improves compatibility with proteins and expands observable processes.

CHRONO participates in multi-modal repression of circadian transcriptional complexes

This paper identifies CHRONO as a repressor of the circadian clock by modulating interactions between BMAL1 and PER2, revealing its role in fine-tuning circadian rhythmicity.

PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period

This study shows that PER phosphorylation inhibits CK1 activity, stabilizing PER and extending circadian period through feedback inhibition.

CRY2 missense mutations suppress P53 and enhance cell growth

The paper identifies CRY2 mutations that suppress P53 and enhance cell growth by disrupting interactions with SCFFBXL3 and affecting circadian rhythms.

Reconstitution of an intact clock that generates circadian DNA binding in vitro

The paper reconstitutes a cyanobacterial circadian clock in vitro to study its control over gene expression and provides a platform for synthetic biology.

Structural mimicry confers robustness in the cyanobacterial circadian clock

The paper shows SasA regulates circadian clock robustness in cyanobacteria by structurally mimicking KaiB to modulate protein complex assembly.

The CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1

The study identifies the CRY1 tail's role in regulating its interaction with CLOCK:BMAL1, affecting circadian timing and linking it to Delayed Sleep Phase Disorder.

Protein dynamics regulate distinct biochemical properties of cryptochromes in mammalian circadian rhythms

The paper identifies a dynamic loop in cryptochromes that regulates their differential binding to CLOCK:BMAL1, explaining their distinct roles in circadian rhythms.

Casein kinase 1 dynamics underlie the PER2 circadian phosphoswitch

This study identifies a molecular switch in CK1 that regulates PER2 stability through substrate selectivity, revealing how kinase mutations affect circadian rhythms across species.