D. M. Virshup

This study investigates how two degrons in PER2 regulate its stability through phosphorylation by CK1, revealing that D1 acts as a backup degron and enables scaffolded phosphorylation in PER1:PER2 dimers.

This study identifies FBXW7 mutations as a mechanism of resistance to anti-Wnt/β-catenin therapies in RNF43-mutant/RSPO-fusion cancers and shows that these tumors are susceptible to multi-CDK inhibition.

This study shows that isoform-specific phosphorylation in the C-terminal tail of CK1δ regulates its autoinhibition and affects circadian rhythms.

This study shows that PER phosphorylation inhibits CK1 activity, stabilizing PER and extending circadian period through feedback inhibition.

This study identifies RNF43 mutations that predict sensitivity to Wnt inhibitors by analyzing their functional impact in vitro and in vivo.

This study identifies a molecular switch in CK1 that regulates PER2 stability through substrate selectivity, revealing how kinase mutations affect circadian rhythms across species.