Author

R. Narasimamurthy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:Drosophila· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. L. Partch· 3 shared D. M. Virshup· 3 shared S. Tripathi· 3 shared A. M. Freeberg· 2 shared C. G. Ricci· 2 shared J. M. Philpott· 2 shared S. R. Hunt· 2 shared C. Lee· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiochemistry

C. L. Partch

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Author profile →

3 papers

Recent·Most cited

Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein Kinase 1

R. L. Harold, N. K. Tulsian, R. Narasimamurthy, N. Yaitanes, M. G. A. Hernandez, H.-W. Lee, P. Crosby, S. Tripathi, D. M. Virshup, C. L. Partch

This study shows that isoform-specific phosphorylation in the C-terminal tail of CK1δ regulates its autoinhibition and affects circadian rhythms.

bioRxiv · Apr 24, 2023Biochemistry

PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period

J. M. Philpott, A. M. Freeberg, J. Park, K. Lee, C. G. Ricci, S. R. Hunt, R. Narasimamurthy, D. H. Segal, R. Robles, Y. D. Cao, S. Tripathi, J. A. McCammon, D. M. Virshup, J. C. Chiu, C. Lee, C. L. Partch

This study shows that PER phosphorylation inhibits CK1 activity, stabilizing PER and extending circadian period through feedback inhibition.

bioRxiv · Jun 24, 2022Biochemistry

Casein kinase 1 dynamics underlie the PER2 circadian phosphoswitch

J. M. Philpott, R. Narasimamurthy, C. G. Ricci, A. M. Freeberg, S. R. Hunt, L. E. Yee, R. S. Pelofsky, S. Tripathi, D. M. Virshup, C. L. Partch

This study identifies a molecular switch in CK1 that regulates PER2 stability through substrate selectivity, revealing how kinase mutations affect circadian rhythms across species.

bioRxiv · Aug 14, 2019Biochemistry