L. Jimenez

Pharmacological Modulation of TRIB2 Stability in Melanoma Reveals CDK12/13 as Dominant Regulators and Potential Therapeutic Targets

This study identifies CDK12/13 as key regulators of TRIB2 stability in melanoma and presents three classes of compounds that effectively eliminate TRIB2 with higher potency than afatinib.

An obligate aerobe adapts to hypoxia by hybridising fermentation with carbon storage

This study reveals how Mycobacterium smegmatis adapts to hypoxia by combining fermentative hydrogen production with carbon storage through lipid droplets.

Culture conditions greatly impact the levels of vesicular and extravesicular Ago2 and RNA in extracellular vesicle preparations.

The paper investigates how culture conditions affect the levels of Ago2 and RNA in extracellular vesicles, finding that serum and cell state influence their presence.

Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids

This study uses patient-derived enteroids to model Microvillus Inclusion Disease and identifies therapeutic strategies targeting Notch signaling and chloride channels.

Atmospheric hydrogen oxidation extends to the domain archaea

This study shows that archaea, like bacteria, oxidize atmospheric hydrogen and carbon monoxide, revealing a cross-domain metabolic trait with ecological and evolutionary significance.

A comparison of survey method efficiency for estimating densities of Zebra Mussels (Dreissena polymorpha)

The paper compares survey methods for estimating zebra mussel densities, finding that efficiency varies with population density and survey design.

Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells

The paper shows that extracellular vesicles from non-neuroendocrine SCLC cells enhance adhesion and survival of neuroendocrine SCLC cells by delivering ECM proteins.

A new method to estimate the ecological niche through n-dimensional hypervolumes that combines convex hulls and elliptical envelopes

This paper introduces a new method to estimate ecological niches by combining convex hulls and elliptical envelopes, showing it produces more accurate hypervolumes than either method alone.

Estimating the fundamental niche: accounting for the uneven availability of existing environmental conditions in the calibration area

This paper proposes a method to estimate the fundamental niche of a species by accounting for environmental condition availability in the calibration area using a weighted-normal model.

Geographic potential of the world largest hornet, Vespa mandarinia Smith (Hymenoptera: Vespidae), worldwide and particularly in North America

The paper assesses the climatic suitability for Asian giant hornet establishment in North America and predicts potential invasive ranges.

On Some Problems of Estimating Fundamental Niche from Physiological Data

The paper identifies challenges in estimating fundamental niches from physiological data and applies solutions to test if fundamental niches contain realized niches in marine fishes and terrestrial beetles, finding agreement with Hutchinson's predictions.

Host sexual dimorphism affects the outcome of within-host pathogen competition

The paper investigates how host sex influences pathogen competition in co-infections, finding that female hosts favor more virulent pathogens while male hosts show neutral or less virulent outcomes.