H.-C. Lee

The HOMEODOMAIN-Like protein HDL mediates chromatin organization and rewires leaf epidermal patterning

This study identifies HDL, a homeodomain-like protein that regulates chromatin organization and influences leaf epidermal cell fate by modulating gene expression and cell heterogeneity.

An obligate aerobe adapts to hypoxia by hybridising fermentation with carbon storage

This study reveals how Mycobacterium smegmatis adapts to hypoxia by combining fermentative hydrogen production with carbon storage through lipid droplets.

P bodies coat germ granules to promote transgenerational gene silencing in C. elegans

This study shows P body factors coat germ granules in C. elegans to enable transgenerational gene silencing by maintaining small RNA factors and secondary small RNA amplification.

Retaining pluripotency and exogenous mRNA introduction in planarian stem cell culture

This study develops methods to culture planarian neoblasts and deliver exogenous mRNAs, demonstrating retained pluripotency and improved yield.

GLH/VASA helicases promote germ granule formation to ensure the fidelity of piRNA-mediated transcriptome surveillance

This study shows that GLH/VASA helicases are essential for forming germ granules, which ensure accurate piRNA-mediated transcriptome surveillance by distinguishing self from non-self.

Maize AFP1 confers antifungal activity by inhibiting chitin deacetylases from a broad range of fungi

This study identifies maize AFP1 as an antifungal protein that inhibits chitin deacetylases in fungi by binding to mannosylated chitin, reducing fungal viability.

Germline RNA helicases couple RNA binding to P granule assembly at nuclear periphery

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.