Y. Jing

Time Resolved Inspection of Ionizable-Lipid Facilitated Lipid Nanoparticle Disintegration and Cargo Release at an Endosomal Membrane Mimic

This study uses TIRF imaging to examine pH-induced LNP fusion and mRNA release, showing delayed fusion onset and rapid cargo escape, with implications for optimizing mRNA delivery.

Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.

This study identifies epithelial NMDA receptors in the kidney that mediate vasodilation via connecting-tubule-glomerular feedback by enhancing ENaC activity.

Comparative analysis of drug-like EP300/CREBBP acetyltransferase inhibitors

This study compares the biochemical and biological potencies of three EP300/CREBBP acetyltransferase inhibitors and demonstrates their utility in investigating epigenetic mechanisms.

Functional divergences of natural variations of TaNAM-A1 controlling leaf senescence initiation during wheat grain filling

This study identifies TaNAM-A1 as a key gene regulating leaf senescence and grain yield in wheat, showing functional differences among its haplotypes.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Increased TCR signaling in regulatory T cells is disengaged from TCR affinity

The paper compares TCR repertoires of regulatory and effector T cells in non-obese diabetic mice, showing similar reactivity but differing suppressive capacity linked to TCR affinity.

Chemoproteomics yields a selective molecular host for acetyl-CoA

The paper develops a chemoproteomics-based method to selectively detect acetyl-CoA using a Nanoluc-NAA50 fusion protein and a ligand displacement assay.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

Three bacterium-plasmid golden combinations facilitate the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

Harnessing Ionic Selectivity In Acetyltransferase Chemoproteomic Probes

The paper develops a CoA-based chemoproteomic strategy to optimize probe selectivity and evaluates its application in assessing small molecule acetyltransferase inhibitors.

Synthesis and Evaluation of a Stable Isostere of Malonyllysine

This study synthesizes and evaluates a stable isostere of malonyllysine, demonstrating its resistance to decarboxylation and antibody recognition.

Identification of sulfenylated cysteines in Arabidopsis thaliana proteins using a disulfide-linked peptide reporter

This study identifies sulfenylated cysteines in Arabidopsis thaliana using a transgenic Yap1 probe, revealing over 1,000 proteins with sulfenylated residues.

MITA couples with PI3K to regulate actin reorganization during BCR activation

This study shows MITA regulates BCR signaling through actin reorganization via the PI3K pathway, affecting B cell differentiation and autoimmune disease.