ImmunologybioRxiv
Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy
R. Basar, N. Uprety, E. Ensley…·K. Rezvani
The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.
DOI 10.1016/j.celrep.2021.109432