Cancer BiologybioRxiv
Simultaneous CRISPR-Cas9-induced double strand breaks are lethal in models of pancreatic cancer
S. S. K. Teh, A. Kotwal, A. Bennett…·J. R. Eshleman
This study shows CRISPR-Cas9-induced DNA double-strand breaks are more cytotoxic to pancreatic cancer cells than radiation-induced breaks, with significant tumor growth inhibition and chromosomal instability.
DOI 10.1172/jci190121