A. Bennett

Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling

This study identifies aberrant transitional alveolar epithelial cells in a mouse fibrosis model and shows they activate fibroblasts through a profibrotic secretome.

A comprehensive evaluation of taxonomic classifiers in marine vertebrate eDNA studies

This study evaluates nine taxonomic classifiers for marine vertebrate eDNA studies, finding MMSeqs2 and Metabuli outperform BLAST in accuracy and reducing false positives.

The adaptive immune response to Trichuris in wild versus laboratory mice: An established model system in context

The paper compares immune responses to Trichuris muris in wild and laboratory mice, finding quantitative differences and age-specific effects in cytokine production and Th1/Th2 balance.

CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers

This paper demonstrates CRISPR-Cas9 can selectively target somatic mutations in pancreatic cancer by exploiting PAMs in noncoding regions, achieving >80% cell death with minimal off-target effects.

Simultaneous CRISPR-Cas9-induced double strand breaks are lethal in models of pancreatic cancer

This study shows CRISPR-Cas9-induced DNA double-strand breaks are more cytotoxic to pancreatic cancer cells than radiation-induced breaks, with significant tumor growth inhibition and chromosomal instability.

Laboratory evaluation of a quaternary ammonium compound (QAC)-based antimicrobial coating used in public transport during the COVID-19 pandemic

This study evaluates the virucidal activity of a QAC-based antimicrobial coating on various materials, finding reduced efficacy with organic debris and limited effectiveness in real-world settings.

Automated optimisation of solubility and conformational stability of antibodies and proteins

This study introduces an automated computational method to co-optimize solubility and conformational stability of antibodies, validated on six antibodies with improved developability without affecting antigen-binding.

LIN37-DREAM Prevents DNA End Resection and Homologous Recombination at DNA Double Strand Breaks in Quiescent Cells

The paper shows LIN37 prevents DNA end resection and HR in quiescent cells independently of 53BP1, unlike in cycling cells.

Adeno-associated virus capsid assembly is divergent and stochastic

This study reveals that AAV capsid assembly is highly stochastic and heterogeneous, with each capsid having a unique composition.

Genomic signatures of evolutionary rescue in bats surviving white-nose syndrome

The paper identifies genomic signatures of evolutionary rescue in bats surviving white-nose syndrome by analyzing genetic changes before and after population decline.

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.