L. Pellegrini

This study identifies a metal ion-dependent mechanism for RAD51 nucleoprotein filament disassembly through cryoEM analysis of ATP and ADP-bound states.

This study reports the cryoEM structure of the SARS-CoV-2 nsp1-primosome complex, revealing how nsp1 interacts with the DNA polymerase-primase complex to disrupt immune responses.

This study presents an atomic model of human CtIP's structure, revealing its extended dimer-of-dimers architecture and dynamic zinc-binding motif involved in DNA repair.

This study shows that LRRK2 mutations sequester Rab8a into lysosomes and disrupt transferrin-mediated iron uptake in microglia, linking LRRK2 dysfunction to iron dysregulation in Parkinson's disease.

The paper identifies CAM833, a small-molecule inhibitor of BRCA2-RAD51 interaction, which disrupts RAD51 assembly and enhances DNA damage-induced cell death in BRCA2-wildtype cells.

The paper reports cryoEM structures of human CMG helicase bound to DNA and AND-1, revealing DNA binding interactions and replisome interactions.

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.

This study provides a structural basis for how Fludarabine and Vidarabine inhibit human primase, suggesting ways to improve their therapeutic efficacy and reduce toxicity.

This study uses cryo-electron tomography and atomic force microscopy to show that SYCP3 forms a flexible fibre that binds DNA, suggesting a mechanism for coating the meiotic chromosome axis.