L. Perera

Structural Basis for pre-tRNA Recognition and Processing by the Human tRNA Splicing Endonuclease Complex

This study presents cryo-EM structures of the human TSEN*pre-tRNA complex, revealing its architecture and tRNA binding interfaces, and provides insights into PCH-causing mutations.

Characterization of SARS2 Nsp15 Nuclease Activity Reveals it's Mad About U

This study characterizes SARS2 Nsp15 nuclease activity, revealing its preference for purines 3 of cleaved uridines and its role in viral RNA processing.

ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

This study shows ISRIB inhibits the integrated stress response by antagonizing eIF2(P)-induced inhibition of eIF2B through allosteric effects.

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15

This study determines the cryo-EM structures of SARS-CoV-2 Nsp15, revealing its active site interactions with uridine and conformational changes, which inform potential therapeutic targets.

A class of GATA3 mutation reprograms the breast cancertranscriptional network through gain and loss of function

This study shows that some GATA3 mutations in breast cancer cause both loss and gain of function, altering the transcriptional network.