T. Ito

Foam rolling intervention improves lactate clearance after high-intensity exercise

This study investigates whether foam rolling improves lactate clearance and cognitive recovery after high-intensity exercise, finding reduced lactate levels and partial executive function recovery.

ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors

This study shows that ILC2s use different S1P receptors at distinct stages to migrate during infection, highlighting a shared vascular network for lymphocyte movement.

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia

This study identifies the taurine-taurine transporter axis as a critical regulator of myeloid leukemia using temporal single-cell RNA-sequencing and functional experiments.

Roles of C/EBPα, GATA2, TGF-β-signaling, and epigenetic regulation in the expression of basophil-specific protease genes

The paper investigates the transcriptional regulation of basophil-specific protease genes Mcpt8 and Mcpt11, identifying C/EBPα, GATA2, TGF-β signaling, and epigenetic factors as key regulators.

NR4A3 deficiency ameliorates contact hypersensitivity and exacerbates psoriasis by regulating gene expression in dendritic cells

This study shows NR4A3 deficiency reduces contact hypersensitivity but worsens psoriasis by altering dendritic cell gene expression.

IGSF3 is a homophilic cell adhesion molecule that drives lung metastasis of melanoma by promoting adhesion to vascular endothelium

Sperm competition influences sperm quality and seminal plasma protein expression among territorial males of the courtship cichlid

The paper examines how sperm competition affects sperm quality and seminal plasma protein expression in cichlid fish, finding correlations between environmental and behavioral factors and these traits.

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature

This study investigates DNA methylation changes during direct reprogramming of mouse embryonic fibroblasts to induced intestinal stem cells, showing similar methylation states between organoid-forming cells and minimal impact on gene expression.

ROR1 plays a critical role in pancreatic tumor-initiating cells with a partial EMT signature.

This study identifies ROR1 as a critical marker for pancreatic tumor-initiating cells with a partial EMT signature, showing its role in promoting tumor growth and relapse.

Hybridization and its impact on the ontogenetic allometry of skulls in macaques

This study examines how hybridization affects skull ontogenetic allometry in macaques, finding additive and transgressive variation in skull shape and maxillary sinus growth.

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

This study identifies human Dectin-1 as a ligand for CLEC-2, showing its O-glycosylation enables it to function as a physiological ligand for immune regulation.

Antiviral effect of candies containing persimmon-derived tannin against SARS-CoV-2 delta strain

This study shows that candies with persimmon-derived tannin reduce SARS-CoV-2 delta variant titers in saliva from healthy volunteers and patients with COVID-19.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Delayed SARS-CoV-2 Spread and Olfactory Cell Lineage Impairment in Close-Contact Infection Syrian Hamster Models

This study investigates SARS-CoV-2 transmission via close contact in Syrian hamsters and shows delayed olfactory cell lineage damage compared to direct infection.

CD8+ T-cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by clonal replacement

The paper tracks CD8+ T-cell clonotypes after three SARS-CoV-2 mRNA vaccinations and finds that clonotypes from earlier shots are replaced by new ones after subsequent boosters.

Identification, expression, and purification of DNA cytosine 5-methyltransferases with short recognition sequences

The paper identifies and characterizes DNA cytosine 5-methyltransferases with short recognition sequences that do not overlap with CG dinucleotides, enabling fine epigenetic mapping.

Unique genomic sequences in a novel Mycobacterium avium subsp. hominissuis lineage enable fine scale transmission route tracing during pig movement

This study identifies a novel Mycobacterium avium subsp. hominissuis lineage in pigs that enables transmission route tracing through unique genetic features.

MitoSearch: Construction of fish species composition database with environmental DNA using public databases

MitoSearch constructs a fish species composition database using environmental DNA and public databases to address issues with existing species distribution data.

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

This study identifies serum albumin concentration as a tertiary risk factor for dialysis-related amyloidosis, showing that maintenance dialysis improves outcomes by increasing serum component concentrations.

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

This study develops a bulk differentiation method for MYOD1-hiPSCs to generate contractile skeletal muscles, improving efficiency and reducing clonal variation compared to clonal methods.

Liver ductal organoids reconstruct intrahepatic biliary trees in decellularized liver grafts

The paper demonstrates that liver ductal organoids can reconstruct intrahepatic bile ducts in decellularized liver grafts, mimicking native liver structure and function.

Characterization of γ-Glutamyl Peptidases and γ-Glutamyl Cyclotransferases for Glutathione Degradation in Arabidopsis

This study identifies GGP1 and GGP3 as key enzymes for glutathione degradation in Arabidopsis, showing they contribute significantly to cytosolic GSH turnover alongside GGCTs.

Bacillus subtilis with a 1% population enhances the activity of Enterococcus faecalis with a 99% population

This study shows that a 1% population of Bacillus subtilis enhances the dye-decolorization activity of a 99% population of Enterococcus faecalis through metabolic interactions.

Machine-learning-guided library design cycle for directed evolution of enzymes: the effects of training data composition on sequence space exploration

This study shows that ML-guided directed evolution can lead to different enzyme variants depending on the presence of a highly positive variant in training data, achieving similar activity improvements.

Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder

The paper investigates Spred2 expression in urothelial tumors and finds it negatively correlates with ERK activation and Ki67 index in non-invasive papillary carcinoma.

Genomic features of Mycobacterium avium subsp. hominissuis isolated from pigs in Japan.

The paper analyzes 30 draft genomes of Mycobacterium avium subsp. hominissuis from Japanese pigs to characterize their genomic features and potential virulence.

The oncogenic Runx3-Myc axis defines p53-deficient osteosarcomagenesis

This study identifies the Runx3-Myc axis as a driver of p53-deficient osteosarcomagenesis in human and mouse models.

Integrated population genomic analysis and numerical simulation to estimate larval dispersal of Acanthaster cf. solaris between Ogasawara and other Japanese regions

This study estimates larval dispersal of Acanthaster cf. solaris between Ogasawara and Kuroshio regions using genomic analysis and oceanographic simulations, finding limited short-term dispersal but gradual long-term connectivity.

Taurine suppresses liquid-liquid phase separation of lysozyme protein

This study shows taurine reduces liquid-liquid phase separation in lysozyme solutions under specific conditions.

Compartmentalized three-dimensional human neuromuscular tissue models fabricated on a well-plate-format microdevice

This study develops a microdevice for compartmentalized coculturing of motor neurons and skeletal muscle tissues to form functional neuromuscular junctions and test drug responses.