Author

L. Roitman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1 Research Focus:ecology & biodiversity· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

V. Krizhanovsky· 2 shared A. Agrawal· 1 shared A. Mayo· 1 shared A. Monsonego· 1 shared A. Nemirovsky· 1 shared A. Shicht· 1 shared A. Zemer· 1 shared E. Eremenko· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

V. Krizhanovsky

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2 papers

Recent·Most cited

ImmunologybioRxivJan 14, 2024

CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging

Y. Elyahu, I. Feygin, N. Pinkas…·A. Monsonego

This study shows CD4 T cells differentiate into cytotoxic T cells in senescent-rich environments, and reducing senescent cells halts this differentiation, impacting aging and disease.

DOI 10.1038/s43587-025-00953-8

mouseexperimental assay

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Cell BiologybioRxivPreprintJan 30, 2023

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells

J. Majewska, A. Agrawal, A. Mayo…·V. Krizhanovsky

This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.

DOI 10.1101/2023.01.30.524522

humanproteomics

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